LATEST!!!

Our broad research interests focus on posttranscriptional gene control. We are specifically interested in understanding the mechanisms of mRNA fate decisions. The question of 'how does a cell decide to translate, store or degrade an mRNA at a given time' intrigues us as a biological problem. This question is relevant because mRNA fate decisions at the level of translation/decay play a critical role in various cellular processes as well as in diseases such as Cancer and Neurodegenerative disorders. We apply a combination of biochemical, genetic, cell biological and genomic approaches to address our research questions. Yeast (S. cerevisiae) is our favourite model organism.

Purusharth I Rajyaguru

Associate Professor

DBT-Wellcome India Alliance Intermediate fellow (2013-2019)

Department of Biochemistry,

Indian Institute of Science

Bangalore-560012

 

Postdoc - University of Arizona, Tucson AZ (2007-2013)

PhD - Centre for Cellular and Molecular Biology, Hyderabad (2001-2007)

M.Sc. - Panjab University, Chandigarh (1997-1999)

B.Sc. - Bhavnagar University, Bhavnagar, Gujarat (1994-1997)

 
 

GROUP MEMBERS

Nupur Bhatter

Ph.D. Student

Raju Roy

Ph.D. Student

Gayatri Mohanan

Int. Ph.D. Student

Mani Garg

Ph.D. Student

Sweta Tiwari

Ph.D. Student

ALUMNI

Poornima G

Debadrita Roy

Monmita Bhar

Sabnam Parbin

Gaurav Srivastava

Rajan Iyappan

Shirish Gole

Rahul Mehta

Vignesh V

Brinta Roy

Shnaya Shah

George Augustine

Sivaji N

Siddharth Kankaria

Mythili Ravishankar

Ishwarya KA

Project Assistant

Amiyaranjan Das

Project Assistant

Sakshi Dewasthale

Ph.D. Student

Chitra Togra

Ph.D. Student

Hanumantha

Lab Assistant

GALLERY

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PUBLICATIONS

  1. Parbin S, Damodharan S and Rajyaguru PI (2021) Arginine methylation and cytoplasmic mRNA fate: An exciting new partnership. Yeast (In press)

  2. Mohanan G, Das A and Rajyaguru PI (2021) Genotoxic stress response: What is the role of cytoplasmic mRNA fate? BioEssays (In press)

  3. Poornima G, Srivastava G, Roy B, Ishwarya KA, Kurbah I, Rajyaguru P (2021): RGG-motif containing mRNA export factor Gbp2 acts as a translation repressor. RNA Biol. 2021 Apr 29;1-12. doi: 10.1080/15476286.2021.1910403

  4. Garg M, Poornima G, Rajyaguru P.I. (2020): Elucidation of the RNA-granule inducing sodium azide stress response through transcriptome analysis. Genomics 112 (2020) 2978–2989. https://doi.org/10.1016/j.ygeno.2020.05.001

  5. Bhatter N, Iyyappan R, Rajyaguru P.I. (2020): Exploring the role of RRM domains and conserved aromatic residues in RGG-motif eIF4G-binding translation repressor protein Sbp1. Version 2. Wellcome Open Res. 2018; 3: 102. doi: 10.12688/wellcomeopenres.14709.2

  6. Parbin S, Mohanan G, Gole S, Joshi D, Bhar M and Rajyaguru PI (2019) DEKTV and YVG motifs in the Lsm domain are important for the activity of Scd6, a conserved translation repressor protein. BBA – Gene Regulatory Mechanisms. BBA - Gene Regulatory Mechanisms 1863 (2020) 1944742. https://doi.org/10.1016/j.bbagrm.2019.194474

  7. Bhatter N, Roy R, Shah S, Sastry SP, Parbin S, Iyappan R, Kankaria S, Rajyaguru PI (2019): Arginine methylation augments Sbp1 function in translation repression and decapping. FEBS J. 2019 Sep 8. doi: 10.1111/febs.15057

  8. Poornima G, Mythili R, Nag P, Parbin S, Verma PK, Hussain T, Rajyaguru PI (2019): RGG-motif self-association regulates eIF4G-binding translation repressor protein Scd6. RNA Biol. 2019 Jun 12:1-13. doi: 10.1080/15476286.2019.1621623.

  9. Roy RRajyaguru PI (2018): Stress Granules and P-Bodies: An Insight into mRNA Translational Control and Decay. Proc Indian Natn Sci Acad 84 No. 2 June 2018 pp. 479-491

  10. Roy DRajyaguru PI (2018): Suppressor of clathrin deficiency (Scd6)-An emerging RGG-motif translation repressor. Wiley Interdiscip Rev RNA. 2018 May 22:e1479. doi: 10.1002/wrna.1479.

  11. Poornima GShah SVignesh VParker RRajyaguru PI (2016): Arginine methylation promotes translation repression activity of eIF4G-binding protein, Scd6. Nucleic Acids Res. 2016 Nov 2;44(19):9358-9368. Epub 2016 Sep 8. 

 
 
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Contact Rajyaguru Lab

IISc Bangalore, Gulmohar Marg, Mathikere, Bengaluru, Karnataka 560012, India

+91-80-2293-2547

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