Our broad research interests focus on posttranscriptional gene control. We are specifically interested in understanding the mechanisms of mRNA fate decisions. The question of 'how does a cell decide to translate, store or degrade an mRNA at a given time' intrigues us as a biological problem. This question is relevant because mRNA fate decisions at the level of translation/decay play a critical role in various cellular processes as well as in diseases such as Cancer and Neurodegenerative disorders. We apply a combination of biochemical, genetic, cell biological and genomic approaches to address our research questions. Yeast (S. cerevisiae) is our favourite model organism.
Purusharth I Rajyaguru
DBT-Wellcome India Alliance Intermediate fellow (2013-2019)
Department of Biochemistry,
Indian Institute of Science
Postdoc - University of Arizona, Tucson AZ (2007-2013)
PhD - Centre for Cellular and Molecular Biology, Hyderabad (2001-2007)
M.Sc. - Panjab University, Chandigarh (1997-1999)
B.Sc. - Bhavnagar University, Bhavnagar, Gujarat (1994-1997)
Parbin S, Damodharan S and Rajyaguru PI (2021) Arginine methylation and cytoplasmic mRNA fate: An exciting new partnership. Yeast (In press)
Mohanan G, Das A and Rajyaguru PI (2021) Genotoxic stress response: What is the role of cytoplasmic mRNA fate? BioEssays (In press)
Poornima G, Srivastava G, Roy B, Ishwarya KA, Kurbah I, Rajyaguru P (2021): RGG-motif containing mRNA export factor Gbp2 acts as a translation repressor. RNA Biol. 2021 Apr 29;1-12. doi: 10.1080/15476286.2021.1910403
Garg M, Poornima G, Rajyaguru P.I. (2020): Elucidation of the RNA-granule inducing sodium azide stress response through transcriptome analysis. Genomics 112 (2020) 2978–2989. https://doi.org/10.1016/j.ygeno.2020.05.001
Bhatter N, Iyyappan R, Rajyaguru P.I. (2020): Exploring the role of RRM domains and conserved aromatic residues in RGG-motif eIF4G-binding translation repressor protein Sbp1. Version 2. Wellcome Open Res. 2018; 3: 102. doi: 10.12688/wellcomeopenres.14709.2
Parbin S, Mohanan G, Gole S, Joshi D, Bhar M and Rajyaguru PI (2019) DEKTV and YVG motifs in the Lsm domain are important for the activity of Scd6, a conserved translation repressor protein. BBA – Gene Regulatory Mechanisms. BBA - Gene Regulatory Mechanisms 1863 (2020) 1944742. https://doi.org/10.1016/j.bbagrm.2019.194474
Bhatter N, Roy R, Shah S, Sastry SP, Parbin S, Iyappan R, Kankaria S, Rajyaguru PI (2019): Arginine methylation augments Sbp1 function in translation repression and decapping. FEBS J. 2019 Sep 8. doi: 10.1111/febs.15057
Poornima G, Mythili R, Nag P, Parbin S, Verma PK, Hussain T, Rajyaguru PI (2019): RGG-motif self-association regulates eIF4G-binding translation repressor protein Scd6. RNA Biol. 2019 Jun 12:1-13. doi: 10.1080/15476286.2019.1621623.
Roy D, Rajyaguru PI (2018): Suppressor of clathrin deficiency (Scd6)-An emerging RGG-motif translation repressor. Wiley Interdiscip Rev RNA. 2018 May 22:e1479. doi: 10.1002/wrna.1479.
Poornima G, Shah S, Vignesh V, Parker R, Rajyaguru PI (2016): Arginine methylation promotes translation repression activity of eIF4G-binding protein, Scd6. Nucleic Acids Res. 2016 Nov 2;44(19):9358-9368. Epub 2016 Sep 8.